CD30-directed Antibody-Tripeptide MMAE Conjugate
PF-08046045 | SGN-35T is an investigational compound. Its safety and efficacy have not been established
Overview + Rationale
- PF-08046045 | SGN-35T is a CD30-directed ADC with the same mAb backbone and cytotoxic monomethyl auristatin E (MMAE) payload as BV and utilizes the novel cleavable tripeptide linker.1
- CD30 is expressed in many B- and T-cell lymphomas while having limited expression in normal tissue2
Mechanism of Action
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Stage of Development
Lymphomas
Phase 1 Monotherapy