CD30-directed Antibody-Tripeptide MMAE Conjugate
PF-08046045, SGN-35T is an investigational compound. Its safety and efficacy have not been established
Overview + Rationale
- PF-08046045; SGN-35T is a CD30-directed ADC with the same mAb backbone and cytotoxic monomethyl auristatin E (MMAE) payload as BV and utilizes the novel cleavable tripeptide linker.
- CD30 is expressed in many B- and T-cell lymphomas while having limited expression in normal tissue2
Mechanism of Action
![](/sites/default/files/2024-05/CD30%20Mechanism.jpg)
Stage of Development
Lymphomas
Phase 1 Monotherapy